Team News: Right back Rafael was forced off at half-time in United’s 4-1 win over Aston Villa and the Brazilian is doubtful for this tie.
Central defenders Rio Ferdinand and Jonny Evans are also nursing back and calf injuries respectively, but they took part in light training on Monday.
Antonio Valencia, who missed the last game with a knee injury, could also return to the starting line-up.
French left-back Patrice Evra is suspended for this game, with Alex Buttner likely to replace him.
Moyes deployed Ryan Giggs at the heart of midfield in the 3-0 victory over Olympiakos, and the veteran is likely to start alongside Michael Carrick.
Juan Mata is ineligible so expect Shinji Kagawa to play in the no 10 role, with Danny Welbeck shifting out to the left.
Prediction: 1-2; This is the biggest game of the season for United, and they will be charged up for this. But do they have enough quality to snatch victory at Old Trafford?