The Blues have kept themselves busy in the transfer market so far. The Londoners have agreed a deal to sign Mohamed Salah from Basel, who is seen as a direct replacement for departing Juan Mata.
In the defence, expect veteran John Terry to be given some rest, with Mourinho may go with David Luiz and Gary Cahill at the back.
Nemanja Matic, the new January signing could make his first start at the Bridge and the Serbian is likely to partner Frank Lampard in the centre.
The departure of Mata and De Bruyne would allow Andre Schurrle to enjoy more game time from now on. Expect the German star to start in place of Eden Hazard, while Demba Ba may start as a lone striker upfront.
Prediction: 2-0; Chelsea are rampant at home this season and expect the Blues to move to the next round with ease.