Ahead of the match, David Moyes has hinted that he could make several changes, as the Scot will be looking to keep the squad fresh in the busy festive period.
The Red Devils are heading into this tie on the back of a convincing 3-0 victory against Aston Villa, but will need to put together a run-of-results to keep the momentum going.
Stoke City on the other hand should be in full of confidence, having remain unbeaten in 3 matches and earned a victory over Chelsea in their last home outing.
Robin van Persie and Michael Carrick will be with injuries, while Nemanja Vidic may return from the knock, but the game may come too soon for him. Javier Hernandez and Shinji Kagawa missed out at the weekend, but could be back in contention here.
Defence: Alex Buttner could be used as left-back while Phil Jones could partner Jonny Evans at the centre, with Rafael playing at right-back.
Midfield: Brazilian midfielder Anderson, who future has been speculated in the media, could come in contention, and might start alongside Tom Cleverley.
Attack: If Kagawa cannot make it to the starting 11, expect young Januzaj to start again. Danny Welbeck will start as lone striker, while Rooney to play as no 10.
Prediction: 1-3; United have won 4 of their last 5 trips to the Brittania and expect them to reach the semi-finals tonight.
Do you agree with the line-up? Let us know below…