The home side are heading into this match on the back of a strong 2-0 victory over Chelsea in the FA Cup and manager Manuel Pellegrini will be hoping for yet another strong result at home.
Team News: City will miss the services of Matija Nastasic through injury, which means Martin Demichelis will partner skipper Kompany at the back.
Brazilian Fernandinho is fit and returned to training but probably Pellegrini will start with Javi Garcia in the middle. Sergio Aguero will miss out, as the Argentine has failed to recover from his injury.
Formation: Pellegrini has used 4-4-2 mainly so far, but will that be an intelligent ploy against a strong team like Barca? Using Dzeko and Negredo together up front can prove to be a huge gamble. A more intelligent decision will be to use Jovetic, who can play as forward as also as an attacking play-maker.
Prediction: 2-1; Barcelona are always an adventurous side and are likely to score, but expect City to score as well and sneak a victory.