David Moyes will be looking to get one over his old side, as the Toffees travel to Manchester for the first time since the Scot took over at the Utd.
Utd are currently on a 12 match unbeaten run in all competitions; but they will have to keep the man who scored a hat-trick at Old Trafford last season, Romelu Lukaku, quiet if they are to extend that record.
Here are the confirmed starting lineups:
Man Utd: De Gea; Rafael, Vidic, Smalling, Evra; Valencia, Fellaini, Giggs, Kagawa, Welbeck; Rooney
Subs: Lindegaard, Evans, Cleverley, Nani, Young, Hernandez, Januzaj
Everton:Howard, Oviedo, Distin, Jagielka (c), Coleman, McCarthy, Barry, Pienaar, Barkley, Mirallas, Lukaku
Subs: Robles, Heitinga, Jelavic, Deulofeu, Naismith, Osman, Stones